Review Talk 1 in the 39th Annual Meeting of the Japanese Society for Immunology
December 2, 2009 at Osaka International Convention Center, Osaka, Japan
by Kenjiro Matsuno, Department of Anatomy (Macro), Dokkyo Medical University
For an effective immune response, immune cell trafficking in the secondary lymphoid organs is crucial. However, the structures for the secondary lymphoid organs that guide this trafficking are still ill defined. This review describes general and specialized structures of rat secondary lymphoid organs, the LNs, spleen, and Peyer's patches. Trafficking patterns of T cell subsets and DC subsets in a steady state and pathological states are described with respect to microstructures and trafficking molecules.
For a convenience of attendants, I recently uploaded important figures and schemes used in my talk in this web site as below. These will be published soon in a review paper in a journal, Arch. Histol. Cytol. It would be a great pleasure of an anatomical immunologist if visitors could find interests in and become a little bit familiar with the morphology of the immune system.
Figures from a review paper in the Arch. Histol. Cytol., in press:
THE MICROSTRUCTURE OF SECONDARY LYMPHOID ORGANS THAT SUPPORT IMMUNE CELL TRAFFICKING
By Matsuno K, Ueta H, Zhou S, Xu XT, Sawanobori Y, Kitazawa Y, Yamashita M, Shi C
Department of Anatomy (Macro), Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan
Index
Fig. 1. A schematic drawing of the lymph node structure and trafficking route for T and B cells.
Fig. 2. A schematic drawing of the spleen and trafficking route of T and B cells.
Fig. 3. A schematic drawing for the structure of Peyer's patches and trafficking route of T and B cells.
Fig. 4. Structural compartments and segregation of immune cells in the LN, spleen and Peyer's patches.
Fig. 5. Specialized structures of the LN for immune cell migration [1].
Fig. 6. Specialized structures of the spleen for immune cell migration.
Fig. 7. Specialized structures of the LN for immune cell migration [2].
Fig. 8. Entrance route for migrating effector cells in the gut and skin.
Fig. 9. A cartoon depicting the trafficking of naive T cell under a normal steady state.
Fig. 10. A cartoon depicting the trafficking of effector and memory T cells after antigen entry.
Fig. 11. A cartoon depicting the danger signal-induced recruitment and trafficking of DC subsets.